Protein Details: Neuronal acetylcholine receptor subunit alpha-7

Protein ID

ICDB_Pro_0510

Protein Name

Neuronal acetylcholine receptor subunit alpha-7

Gene Name

CHRNA7; NACHRA7

Organism

Homo sapiens (Human)

Length

502 amino acids

AlphaFoldDB

AF-P36544-F1-model_v4.pdb

Function

After binding acetylcholine;the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Sequence

MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA

PDB Structures

2MAW 5AFH 5AFJ 5AFK 5AFL 5AFM 5AFN 7EKI 7EKP 7EKT 7KOO 7KOQ 7KOX 7RPM 8C9X 8CAU 8CE4 8CI1 8CI2 8F4V

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

SITE 82: "Key residue that facilitates effective access of the conotoxin BuIA to the channel binding site"; SITE 134: "Key residue for a low dissociation (K(off)) from the conotoxin BuIA"

Disease

Chromosome 15Q13

Location

DOI ID

10.1007/bf02736842; 10.1124/mol.51.2.320; 10.1016/s0014-5793(96)01383-x; 10.1007/pl00010921; 10.1038/nature04601; 10.1101/gr.2596504; 10.1074/jbc.m110454200; 10.1016/0014-5793(92)81411-e; 10.1021/bi048918g; 10.1124/mol.105.017459; 10.1111/jnc.13718

RefSeq

NP_000741.1 [P30926-1]; NP_001243496.1 [P30926-2]